Over the centuries, countless women have turned to false unicorn root (Chamaelirium luteum), a tall perennial native to eastern North America, to remedy menstrual and uterine problems. (It should not be confused with Aletris farinosa, another member of the lily family, commonly referred to as “true” unicorn root.) Therapeutic compounds called steroidal saponins were identified in false unicorn root some time ago, but whether these exert hormonal activity in women that would help regulate the menstrual cycle remains unclear.